![]() Chronic inflammation, mitochondria decline, altered energy metabolism, and dysregulated stress response systems and their potential etiological roles in frailty will be discussed. This symposium provides an overview of progress in physical frailty research to date, and a roadmap for future high priority frailty research in the biological, measurement, clinical implementation, and public health domainsĬommunication 1: Biological Research Priorities, Jeremy Walston (Johns Hopkins University, Baltimore, MD, USA)Īge-related molecular changes and dysregulation of physiological systems have long been hypothesized to drive the development of physical frailty. A group of frailty-focused investigators centered at Johns Hopkins University have convened a bimonthly frailty working group and identified several major areas of frailty research that would benefit from increased focus. Despite this progress, there remain considerable gaps in knowledge related to frailty measurement, biological etiologies, implementation of frailty into clinical practice, and public health measures to prevent and ameliorate frailty. Over the past 2 decades, great progress has been made in developing frailty assessment methods, understanding the consequences of frailty, and in identifying important biological characteristics related to physical frailty. ![]() Jeremy Walston (Johns Hopkins University, Baltimore, Maryland, USA) ![]() ![]() S1- A ROAD MAP FOR THE DEVELOPMENT OF HIGH PRIORITY PHYSICAL FRAILTY RESEARCH. ![]()
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